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Marein
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Marein图片
CAS NO:535-96-6
包装:5mg
市场价:2250元

产品介绍
Marein通过减少对线粒体功能的损害和AMPK信号通路的激活而具有神经保护作用。Marein通过CaMKK/AMPK/GLUT1促进葡萄糖摄取,通过IRS/Akt/GSK-3β增加糖原合成,并通过Akt/FoxO1减少糖异生,从而改善HepG2细胞中高葡萄糖诱导的胰岛素抵抗。Marein是一种HDAC抑制剂,IC50为100µM。Marein具有有益的抗氧化,降压,降血脂和抗糖尿病作用。
Cas No.535-96-6
别名马里甙
Canonical SMILESO=C(C1=CC=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)C(O)=C1O)/C=C/C3=CC=C(O)C(O)=C3
分子式C21H22O11
分子量450.39
溶解度DMSO: soluble
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects[1][2][3].

[1]. Baoping Jiang, et al. Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells. Phytomedicine. 2016 Aug 15;23(9):891-900. [2]. Baoping Jiang, et al. Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells. Free Radic Res. 2016;50(11):1173-1187. [3]. B Orlikova, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805.