ETP 45658

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ETP 45658

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1198357-79-7

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议

产品介绍

ETP 45658 是一种有效的 PI3K 抑制剂，对 PI3Kα、PI3Kδ、PI3Kβ 和 PI3Kγ 的 IC50 分别为 22.0 nM、39.8 nM、129.0 nM 和 717.3 nM。 ETP 45658 还可以抑制 DNA-PK (IC50\u003d70.6 nM) 和 mTOR (IC50\u003d152.0 nM)。 ETP 45658 可用于癌症研究。

Cas No.	1198357-79-7
Canonical SMILES	CN2C1=NC(C3=CC(O)=CC=C3)=NC(N4CCOCC4)=C1C=N2
分子式	C₁₆H₁₇N₅O₂
分子量	311.34
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo. Link et al (2009) Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases. J.Biol.Chem. 284 28392 PMID:19690175 \|Hill et al (2014) A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. Breast Cancer Res. 16 482 PMID:25488803