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Hematein
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hematein图片
CAS NO:475-25-2
包装与价格:
包装价格(元)
500mg电议
1g电议
5g电议
10g电议

产品介绍
Hematein 是苏木精的氧化产物,可作为染料。Hematein 是一种变构酪蛋白激酶 II 抑制剂,IC50 为 0.74 μM。Hematein 抑制 Akt/PKB Ser129 磷酸化,Wnt/TCF 途径并增加肺癌细胞的凋亡。
Cas No.475-25-2
别名氧化苏木精
Canonical SMILESO=C1C=C2CC3(C(C4=CC=C(C(O)=C4OC3)O)=C2C=C1O)O
分子式C16H12O6
分子量300.26
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].

[1]. Shirai, K., & Matsuoka, M. (1996). Structure and properties of hematein derivatives. Dyes and Pigments, 32(3), 159-169. [2]. Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43(5):1517-22.