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Nepodin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nepodin图片
CAS NO:3785-24-8
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Nepodin (Musizin) 是一种醌氧化还原酶 (PfNDH2) 抑制剂,从 Rumex crispus 中分离。Nepodin (Musizin) 通过激活 AMPK 刺激 GLUT4 向质膜的转运。Nepodin (Musizin) 具有抗糖尿病和抗疟疾的作用。
Cas No.3785-24-8
别名羊蹄素,Musizin
Canonical SMILESCC(C1=C(C)C=C2C=CC=C(O)C2=C1O)=O
分子式C13H12O3
分子量216.23
溶解度Methanol: soluble
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1].

Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2]. Animal Model: C57BL/KsJ-db/db mice[2]

[1]. Lee KH, et al. Antimalarial activity of nepodin isolated from Rumex crispus. Arch Pharm Res. 2013 Apr;36(4):430-5. [2]. Ha BG, et al. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug;40(4):436-47.