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Umbralisib R-enantiomer
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Umbralisib R-enantiomer图片
CAS NO:1532533-69-9
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) 是 PI3Kδ 抑制剂,是 TGR-1202 活性较低的对映体。
Cas No.1532533-69-9
别名TGR-1202 R-enantiomer; RP5264 R-enantiomer
Canonical SMILESO=C1C(C2=CC=CC(F)=C2)=C([C@@H](C)N3N=C(C4=CC=C(OC(C)C)C(F)=C4)C5=C(N)N=CN=C53)OC6=CC=C(F)C=C16
分子式C31H24F3N5O3
分子量571.55
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202. PI3Kδ

Umbralisib R-enantiomer (TGR-1202 R-enantiomer) (Formula A) exhibits a 50% inhibitory concentration (IC50) with respect to the δ type PI3-kinase that is at least 20-fold lower than the inhibitor's IC50 with respect to the rest of the other PI3K isoforms (i.e., a, β, and γ)[1].

[1]. Michael Weiss, et al. Combination of anti-cd20 antibody and pi3 kinase selective inhibitor. WO2014071125A1.