Indirubin-5-sulfonate

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CAS NO:

244021-67-8

包装与价格：

包装	价格(元)
250mg	电议
500mg	电议

产品介绍

Indirubin-5-sulfonate 是周期蛋白依赖性激酶(CDK) 的抑制剂，对CDK1/cyclin B、CDK2/cyclin A、CDK2/cyclin E、CDK4/cyclin D1 和CDK5/p35 的IC50 值分别为55 nM、35 nM、150 nM、300 nM 和 65 nM。Indirubin-5-sulfonate 同样能抑制GSK-3β 的活性。

Cas No.	244021-67-8
Canonical SMILES	O=S(C1=CC2=C(NC(/C2=C3NC4=C(C=CC=C4)C/3=O)=O)C=C1)(O)=O
分子式	C₁₆H₁₀N₂O₅S
分子量	342.33
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2]. Cdk1/cyclin B\|55 nM (IC50)\|cdk2/cyclin A\|35 nM (IC50)\|CDK2/cyclinE\|150 nM (IC50)\|Cdk4/cyclin D1\|300 nM (IC50)\|CDK5/p35\|65 nM (IC50)\|GSK-3β [1]. Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7. [2]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors• J Biol Chem. 2001 Jan 5;276(1):251-60.