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FT-1518
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
FT-1518图片
CAS NO:1313026-58-2
包装与价格：
包装价格(元)
250mg电议
500mg电议

产品介绍
FT-1518是一种选择性的，可口服的，有效的新一代mTORC1和mTORC2抑制剂，具有抗肿瘤的活性。
Cas No.1313026-58-2
Canonical SMILESCCC(N1C2=NC(N3CC4OC(CC4)C3)=NC(C5=NC=C(N)N=C5)=C2N=C1)CC
分子式C20H26N8O
分子量394.47
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity.

FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518 displays significant growth inhibitory activity against a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. FT-1518 cuases potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)] in cells[1].

FT-1518 exhibits dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts[1].

[1]. Alain C. Mita, et al. Abstract 137: FT-1518, a new generation selective and potent mTORC1 and mTORC2 inhibitor: an in vitro and in vivo profile. Cancer Res 2017;77(13 Suppl).