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ML303
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML303图片
CAS NO:1638211-04-7
包装:1mg
市场价:2070元

产品介绍
ML303 是一种吡唑并吡啶类化合物, 是流感病毒非结构蛋白 1 (NS1) 的拮抗剂 (IC90 为 155 nM),其对流感病毒H1N1亚型的 EC50 值为0.7 μM。
Cas No.1638211-04-7
分子式C21H16F3N3O2
分子量399.37
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].

ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells[1].

[1]. Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119.