CAS NO: | 2237925-62-9 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Cas No. | 2237925-62-9 |
分子式 | C16H18ClN7O |
分子量 | 359.81 |
溶解度 | DMSO : 50 mg/mL (138.96 mM; ultrasonic and warming and heat to 60℃) |
储存条件 | 4°C, away from moisture |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1]. [1]. Davila-Calderon J, Patwardhan NN, Chiu LY, et al. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun. 2020;11(1):4775. Published 2020 Sep 22. |