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DMA-135 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DMA-135 hydrochloride图片
CAS NO:2237925-62-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
DMA-135 hydrochloride 抑制肠道病毒 71 型 (EV71) IRES依赖的翻译和复制。DMA-135 hydrochloride 以中等高亲和力(KD=?520? nM) 结合 EV71 的 SLII 结构域。DMA-135 hydrochloride 在基于细胞的研究中没有显著毒性。
Cas No.2237925-62-9
分子式C16H18ClN7O
分子量359.81
溶解度DMSO : 50 mg/mL (138.96 mM; ultrasonic and warming and heat to 60℃)
储存条件4°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1].

[1]. Davila-Calderon J, Patwardhan NN, Chiu LY, et al. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun. 2020;11(1):4775. Published 2020 Sep 22.