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WCK-4234
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WCK-4234图片
CAS NO:1804915-68-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
WCK-4234 是一种有效的 β-内酰胺酶抑制剂。WCK-4234 抑制 A、C 和 D 类 β-内酰胺酶活性。WCK-4234 缺乏直接的抗菌活性。WCK-4234 通过OXA-48/OXA-181 或 KPC 酶,或结合不渗透性, AmpC 或 ESBL 活性,增强亚胺培南和美罗培南对肠杆菌科细菌的抗菌作用作用。WCK-4234 明显克服了由 OXA (class D) 型碳青霉烯酶介导的抗性。
Cas No.1804915-68-1
别名阿维巴坦杂质46
分子式C7H8N3NaO5S
分子量269.21
储存条件-20°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases[1][2].

[1]. Iregui A, et al. Activity of Meropenem with a Novel Broader-Spectrum β-Lactamase Inhibitor, WCK 4234, against Gram-Negative Pathogens Endemic to New York City. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01666-19.
[2]. Mushtaq S, et al. WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1688-1695.