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Lefamulin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lefamulin图片
CAS NO:1061337-51-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Lefamulin (BC-3781) 是一种口服活性抗生素。
Cas No.1061337-51-6
别名来法莫林,BC-3781
Canonical SMILESO=C1CC[C@@]2(CC[C@H]3C)[C@@H](C)[C@H](O)[C@@](C=C)(C)C[C@@H](OC(CS[C@@H]4CC[C@@H](N)C[C@H]4O)=O)[C@@]3(C)[C@@]21[H]
分子式C28H45NO5S
分子量507.7
溶解度DMF: 16 mg/mL,DMSO: 12 mg/mL,Ethanol: 3 mg/mL,PBS (pH 7.2): 0.25 mg/mL
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lefamulin is a pleuromutilin antibiotic.1It is active against methicillin-resistantS. aureus(MRSA),S. pyogenes,E. faecium,H. influenzae,M. catarrhalis,L. pneumonophilia,C. pneumoniae, andM. pneumoniae(MIC50s = 0.006-1 µg/ml). Lefamulin is also active against fluoroquinolone- and macrolide-resistant strains ofN. gonorrhoeae(MIC90s = 1 mg/L for all).In vivo, lefamulin (10-40 mg/kg) reduces the number of colony-forming units (CFUs) in a mouse model ofS. pneumoniaethigh infection.2It also reduces LPS-induced production of TNF-α, IL-6, IL-1β, and GM-CSF, bronchoalveolar lavage fluid (BALF) neutrophil infiltration, and lung matrix metalloproteinase-9 (MMP-9) levels in a mouse model of LPS-induced neutrophilia.3Formulations containing lefamulin have been used in the treatment of community-acquired bacterial pneumonia (CABP).

1.Veve, M.P., and Wagner, J.L.Lefamulin: Review of a promising novel pleuromutilin antibioticPharmacotherapy38(9)935-946(2018) 2.Wicha, W.W., Craig, W.A., and Andes, D.In vivo pharmacodynamics of lefamulin, the first systemic pleuromutilin for human use, in a neutropenic murine thigh infection modelJ. Antimicrob. Chemother.74(Suppl 3)iii5-iii10(2019) 3.Hafner, M., Paukner, S., Wicha, W.W., et al.Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse modelPLoS One16(9)e0237659(2022)