Brevetoxin 3

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Brevetoxin 3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Brevetoxin 3图片

CAS NO:	85079-48-7
包装:	100 µg
市场价:	5292元

产品介绍

Brevetoxin 3 (PbTx-3) 是一种有效的变构电压门控 Na+ 通道激活剂，具有多个活性中心（A 环内酯，R 侧链的 C-42）。

Cas No.	85079-48-7
别名	PbTx-3
Canonical SMILES	C[C@@]12[C@](C[C@@]3([H])[C@](O2)(CC[C@@]4([H])[C@]([C@@H](C[C@@]5([H])[C@](C[C@]6([C@](C[C@@]7([H])[C@](C(C)=CC(O7)=O)([H])O6)([H])O5)C)([H])O4)C)([H])O3)C)([H])O[C@@]8([C@@](O[C@]9([H])[C@@](O[C@]%10([H])[C@@](O[C@@]%11([C@@](O[C@@H](C[C@@H]%11O)CC(CO)=C)([H])C%10)C)([H])C9)([H])C=CC8)([H])C1)C
分子式	C₅₀H₇₂O₁₄
分子量	897.1
溶解度	DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Brevetoxin 3 is a neurotoxin produced by the dinoflagellateK. brevis.^1,2It binds to site 5 of voltage-gated sodium channels (Na_vs), prolonging the mean open time and inhibiting inactivation of these channels.²Brevetoxin 3 induces the release of lactate dehydrogenase (LDH), L-glutamate, and L-aspartate from primary rat cerebellar granule neurons (CGNs; EC₅₀s = 30.9, 45.3, and 50.2 nM, respectively).³It induces convulsions in, and is lethal to (LD₅₀= 4 ng/egg), Japanese rice fish embryos.¹Brevetoxin 3 has been found in water samples collected during red tide blooms.⁴ 1.Colman, J.R., and Ramsdell, J.S.The type B brevetoxin (PbTx-3) adversely affects development, cardiovascular function, and survival in Medaka (Oryzias latipes) embryosEnviron. Health Perspect.111(16)1920-1925(2003) 2.Jeglitsch, G., Rein, K.S., Baden, D.G., et al.Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neuronsJ. Pharmacol. Exp. Ther.284(2)516-525(1997) 3.Berman, F.W., and Murray, T.F.Brevetoxins cause acute excitotoxicity in primary cultures of rat cerebellar granule neuronsJ. Pharmacol. Exp. Ther.290(1)439-444(1999) 4.Pierce, R.H., and Henry, M.S.Harmful algal toxins of the Florida red tide (Karenia brevis): Natural chemical stressors in South Florida coastal ecosystemsEcotoxicology17(7)623-631(2008)