生物活性
UNC0642是有效的选择性G9a和GLP组蛋白赖氨酸甲基转移酶抑制剂（IC50 <2.5 nM）。它降低了MDA-MB-231细胞中的H3K9二甲基化水平（IC50 = 110 nM）。在体内显示适度的大脑渗透。
化学数据
| 目录号 | A15487 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 546.69 |
| Formula | C29H44F2N6O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1481677-78-4 |
| Synonyms | UNC 0642, UNC-0642 |
| SMILES | CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F |
溶解度
| In vitro | DMSO | 88 mg/mL (160.96 mM) |
| Water | Insoluble |
| Ethanol | 88 mg/mL (160.96 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 18.29 mL | 91.46 mL | 182.92 mL |
| 0.5 mM | 3.66 mL | 18.29 mL | 36.58 mL |
| 1 mM | 1.83 mL | 9.15 mL | 18.29 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
*The above data is based on the productmolecular weight 546.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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