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N-Nitroso Metoprolol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Nitroso Metoprolol图片
CAS NO:138768-62-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A genotoxic derivative of metoprolol
Cas No.138768-62-4
Canonical SMILESO=NN(C(C)C)CC(COC1=CC=C(CCOC)C=C1)O
分子式C15H24N2O4
分子量296.4
溶解度Acetonitrile: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Nitroso metoprolol is a genotoxic derivative of metoprolol .1,2It induces DNA fragmentation in rat hepatocytes when used at concentrations ranging from 0.1 to 1 mM.1In vivo, N-nitroso metoprolol (1,000 mg/kg) induces micronucleation of rat hepatocytes but not erythrocytes from the bone marrow or spleen.

1.Robbiano, L., Martelli, A., Allavena, A., et al.Formation of the N-nitroso derivatives of six β-adrenergic-blocking agents and their genotoxic effects in rat and human hepatocytesCancer Res.51(9)2273-2279(1991) 2.Martelli, A., Allavena, A., Sottofattori, E., et al.Low clastogenic activity in vivo of the N-nitroso derivatives of 5 β-adrenergic-blocking drugs proved to be potent genotoxins in vitroToxicol. Lett.73(3)185-191(1994)