CAS NO: | 138768-62-4 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Cas No. | 138768-62-4 |
Canonical SMILES | O=NN(C(C)C)CC(COC1=CC=C(CCOC)C=C1)O |
分子式 | C15H24N2O4 |
分子量 | 296.4 |
溶解度 | Acetonitrile: 10 mg/ml |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | N-Nitroso metoprolol is a genotoxic derivative of metoprolol .1,2It induces DNA fragmentation in rat hepatocytes when used at concentrations ranging from 0.1 to 1 mM.1In vivo, N-nitroso metoprolol (1,000 mg/kg) induces micronucleation of rat hepatocytes but not erythrocytes from the bone marrow or spleen. 1.Robbiano, L., Martelli, A., Allavena, A., et al.Formation of the N-nitroso derivatives of six β-adrenergic-blocking agents and their genotoxic effects in rat and human hepatocytesCancer Res.51(9)2273-2279(1991) 2.Martelli, A., Allavena, A., Sottofattori, E., et al.Low clastogenic activity in vivo of the N-nitroso derivatives of 5 β-adrenergic-blocking drugs proved to be potent genotoxins in vitroToxicol. Lett.73(3)185-191(1994) |