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GSK579289A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK579289A图片
CAS NO:929095-23-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A Plk1 inhibitor
Cas No.929095-23-8
Canonical SMILESC[C@H](C1=C(C=CC=C1)Cl)OC(C=C2N3C4=CC(OC5CCN(CC5)C)=CC=C4N=C3)=C(S2)C(N)=O
分子式C26H27ClN4O3S
分子量511
溶解度DMSO: 25 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GSK579289A is an inhibitor of polo-like kinase 1 (Plk1; IC50= 2 nM).1It is selective for Plk1 over Plk3 (IC50= 630 nM). GSK579289A inhibits proliferation of HCT116 cells (IC50= 11 nM).

1.Rheault, T.R., Donaldson, K.H., Badiang-Alberti, J.G., et al.Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like propertiesBioorg. Med. Chem. Lett.20(15)4587-4592(2010)