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4-oxo Isotretinoin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-oxo Isotretinoin图片
CAS NO:71748-58-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
An active metabolite of isotretinoin
Cas No.71748-58-8
别名4-酮13-顺式维甲酸
Canonical SMILESOC(/C=C(C)\C=C\C=C(C)\C=C\C(C(C)(CC1)C)=C(C)C1=O)=O
分子式C20H26O3
分子量314.4
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 15 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-oxo Isotretinoin is an active metabolite of the retinoid isotretinoin .1It is formed from isotretinoin by several cytochrome P450 (CYP450) isoforms, including CYP3A, CYP2B6, and CYP2C19.24-oxo Isotretinoin (10 µM) increases protein expression of cytokeratin 7 (CK7) and CK19 in normal human epidermal keratinocytes.3It inhibits proliferation of retinoid-sensitive UM-SCC-22A and UM-SCC-35 head and neck squamous cell carcinoma (HNSCC) cells in a concentration-dependent manner.44-oxo Isotretinoin has been found in influent and effluent wastewater.5It is teratogenic to mouse embryos when administered to pregnant dams at a dose of 100 mg/kg on day 11 of gestation.6

1.Colburn, W.A., Vane, F.M., and Shorter, H.J.Pharmacokinetics of isotretinoin and its major blood metabolite following a single oral dose to manEur. J. Clin. Pharmacol.24(5)689-694(1983) 2.Sonawane, P., Cho, H.E., Tagde, A., et al.Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastomaBr. J. Pharmacol.171(23)5330-5344(2014) 3.Baron, J.M., Heise, R., Blaner, W.S., et al.Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitroJ. Invest. Dermatol.125(1)143-153(2005) 4.Klaassen, I., Brakenhoff, R.H., Smeets, S.J., et al.Metabolism and growth inhibition of four retinoids in head and neck squamous normal and malignant cellsBr. J. Cancer85(4)630-635(2001) 5.Yeung, K.W.Y., Zhou, G.-J., HilscherovÁ, K., et al.Current understanding of potential ecological risks of retinoic acids and their metabolites in aquatic environmentsEnviron. Int.136105464(2020) 6.Kochhar, D.M., and Penner, J.D.Developmental effects of isotretinoin and 4-oxo-isotretinoin: The role of metabolism in teratogenicityTeratology36(1)67-75(1987)