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Racecadotril-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Racecadotril-d5图片
CAS NO:1246815-11-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An internal standard for the quantification of racecadotril
Cas No.1246815-11-1
别名消旋卡多曲杂质,Acetorphan-d5
Canonical SMILES[2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1COC(CNC(C(CSC(C)=O)CC2=CC=CC=C2)=O)=O
分子式C21H18D5NO4S
分子量390.5
溶解度DMSO: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Racecadotril-d5is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan .1,2In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively.1It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-induced diarrhea.2Formulations containing racecadotril have been used in the treatment of acute diarrhea.

1.Griggs, D.W., Prinsen, M.J., Oliva, J., et al.Pharmacologic comparison of clinical neutral endopeptidase inhibitors in a rat model of acute secretory diarrheaJ. Pharmacol. Exp. Ther.357(2)423-431(2016) 2.Bui, T., Li, G., Kim, I., et al.Effects of racecadotril on weight loss and diarrhea due to human rotavirus in neonatal gnotobiotic pigs (Sus scrofa domesticus)Comp. Med.67(2)157-164(2017)