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GLPG2451
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GLPG2451图片
CAS NO:2055015-61-5
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
GLPG2451 是一种囊性纤维化跨膜电导调节器 (CFTR) 的增强剂，有效增强低温挽救的 F508del CFTR，EC50 为 11.1 nM。
Cas No.2055015-61-5
Canonical SMILESO=S(C1=CC=C(OC(F)(F)F)C=C1)(C2=CN=C(C(NC[C@@H](O)C)=O)C(N)=C2)=O
分子式C16H16F3N3O5S
分子量419.38
溶解度DMSO: 270 mg/mL (643.81 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1]. Cystic fibrosis transmembrane conductance regulator[1]

GLPG2451 has an EC50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells[1].

[1]. Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221.