| CAS NO: | 2415263-08-8 |
| 包装: | 10mg |
| 市场价: | 2573元 |
| Cas No. | 2415263-08-8 |
| Canonical SMILES | ClC(C=C1)=CC(C(NC2=CC=C3C=CS(=O)(C3=C2)=O)=O)=C1OCCCN.Cl |
| 分子式 | C18H17ClN2O4S.HCl |
| 分子量 | 429.32 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | STAT3 inhibitor. Downregulates phosphorylation of STAT3 and increases the expression of cleaved caspase-3. Inhibits cell-cycle progression and proliferation in breast and pancreatic cancer cells in vitro (IC50 values are in the range 0.04 - 1.97 μM). Also inhibits growth of ER-negative breast cancer xenografts in mice. Orally bioavailable. Chen et al (2014) Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur.J.Med.Chem. 82 195 PMID:24904966 |
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