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EGFR-IN-7
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
EGFR-IN-7图片
CAS NO:2267329-76-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
EGFR-IN-7 (compound 34) 是一种有效选择性的 EGFR 激酶抑制剂，对 EGFR (WT) 和 EGFR (mutant C797S/T790M/L858R) 的 IC50 值分别为 7.92 nM 和 0.218 nM，具有抗肿瘤活性，详细信息请参考专利 WO2019015655A1。
Cas No.2267329-76-8
别名5-溴-N4-[5-(二甲基膦基)-6-喹喔啉基]-N2-[2-甲氧基-5-甲基-4-[4-(4-甲基-1-哌嗪基)-1-哌啶基]苯基]-2,4-嘧啶二胺
Canonical SMILESCN1CCN(C2CCN(C3=C(C)C=C(NC4=NC=C(Br)C(NC5=CC=C6N=CC=NC6=C5P(C)(C)=O)=N4)C(OC)=C3)CC2)CC1
分子式C32H41BrN9O2P
分子量694.6
溶解度DMSO: 5 mg/mL (7.20 mM; ultrasonic and warming and adjust pH to 5 with 0.1 M HCL and heat to 60℃)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

EGFR-IN-7 (compound 34) is a selective and potent EGFR kinase inhibitor extracted from patent WO2019015655A1, has IC50s of 7.92 nM and 0.218 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively, and shows anti-tumor activity[1]. EGFR (WT)|7.92 nM (IC50)|EGFR (C797S/T790M/L858R)|0.218 nM (IC50)

[1]. Aryl-phosphorus-oxygen compound as egfr kinase inhibitor.