您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > ML115
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
ML115
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML115图片
CAS NO:912798-42-6
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
Cas No.912798-42-6
Canonical SMILESCOC1=CC(NC(C2=NOC(C3CC3)=C2)=O)=C(OC)C=C1Cl
分子式C15H15ClN2O4
分子量322.7
溶解度DMF: 25 mg/ml,DMSO: 16 mg/ml,Ethanol: 0.1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB. It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6. As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.