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Ascochlorin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ascochlorin图片
CAS NO:26166-39-2
包装与价格:
包装价格(元)
500μg电议
2.5mg电议

产品介绍
Ascochlorin (Ilicicolin D) 是一种类异戊二烯抗生素,主要通过抑制 STAT3 信号级联来介导其抗肿瘤作用。
Cas No.26166-39-2
别名壳二孢氯素,Ilicicolin D
Canonical SMILESOC1=C(Cl)C(C)=C(C([H])=O)C(O)=C1C/C=C(C)/C=C/[C@]2(C)[C@@H](C)C(CC[C@H]2C)=O
分子式C23H29ClO4
分子量404.9
溶解度DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ascochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells. It suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 µM) by inhibiting the expression of matrix metalloproteinase-9. At 2 µM, ascochlorin profoundly increases the expression of p53 by increasing protein stability in cancer cells, and, at 50 µm, it inhibits signaling through STAT3. Ascochlorin also binds and inhibits the mitochondrial cytochrome bc1 complex, blocking reduction of cytochrome b by ubiquinone.