CAS NO: | 2091134-35-7 |
包装 | 价格(元) |
250mg | 电议 |
500mg | 电议 |
Cas No. | 2091134-35-7 |
Canonical SMILES | O=C(NC1=CC=CC2=C1NC=C2C3=C(C=NC(NC4=CN(N=C4OC)C)=N3)F)[C@H](N5CCN([C@@H](C5)C)C)C |
分子式 | C26H32FN9O2 |
分子量 | 521.59 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1]. [1]. Annika Birgitta Margareta ?STRAND, et al. Compounds and methods for inhibiting jak. |