| CAS NO: | 802555-85-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 802555-85-7 |
| 别名 | M36 |
| Canonical SMILES | O=C(NCCCNC(NC1=CC=CC(C2=NCCN2)=C1)=O)NC3=CC=CC(C4=NCCN4)=C3 |
| 分子式 | C23H28N8O2 |
| 分子量 | 448.52 |
| 溶解度 | DMSO: 5 mg/mL (11.15 mM; ultrasonic and warming and heat to 80℃) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1[1]. p32[1] p32 Inhibitor M36 inhibits SF188 glioma cells proliferation (IC50 of 77.9 μM in complete media) and is much more potent under low glucose conditions with an IC50 of 7.3 μM[1]. p32 Inhibitor M36 is selective for p32 overexpressing cells[1].p32 Inhibitor M36 is also a potent inhibitor of patient-derived neurospheres with an IC50 of 2.8 μM[1]. [1]. Yenugonda V,et al. A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma. J Transl Med. 2017 Oct 18;15(1):210. |
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