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Prostratin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Prostratin图片
CAS NO:60857-08-1
包装与价格：
包装价格(元)
500 μg电议
5mg电议
10mg电议
1mg电议

产品介绍
An HIV reactivator
Cas No.60857-08-1
别名13-O-乙酰基-12-脱氧佛波醇,13-O-Acetylphorbol
化学名9a-(acetyloxy)-1,1aR,1bS,4,4aR,7aS,7bR,8R,9,9aS-decahydro-4a,7b-dihydro-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
Canonical SMILESOCC1=C[C@H]2[C@H]3[C@@](OC(=O)C)(C[C@@H](C)C2(O)C2C=C(C)C(=O)[C@@]2(O)C1)C3(C)C
分子式C22H30O6
分子量390.5
溶解度10mg/mL in DMSO,10mg/mL in DMF, 10mg/mL in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC50 value of ~0.5 &#181M. [1] Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. [2] The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.[3][4][5]

Reference:
[1]. Bedoya, L.M., Márquez, N., Martínez, N., et al. SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vivo. Biochemical Pharmacology 77, 965-978 (2009).
[2]. Wender, P.A., Kee, J.M., and Warrington, J.M. Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV. Science 320, 649-652 (2008).
[3]. Williams, S.A., Chen, L.F., Kwon, H., et al. Prostratin antagonizes HIV latency by activating NF- k B. The Journal of Biological Chemisty 279(40), 42008-42017 (2004).
[4]. Biancotto, A., Grivel, J.C., Gondois-Rey, F., et al. Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue. Journal of Virology 78(19), 10507-10515 (2004).
[5]. Hezareh, M., Moukil, M.A., Szanto, I., et al. Mechanisms of HIV receptor and co-receptor down-regulation by prostratin: Role of conventional and novel PKC isoforms. Antivir. Chem. Chemother. 15, 207-222 (2004).