PPY A 是一种有效的 T315I 突变体和野生型 Abl 激酶抑制剂，IC50 分别为 9 和 20 nM。 PPY A 抑制用野生型 Abl 和 Abl T315I 突变体转化的 Ba/F3 细胞，IC50 分别为 390 和 180 nM。 PPY A可用于慢性粒细胞白血病（CML）的研究。
| Cas No. | 875634-01-8 |
| 化学名 | 5-[3-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylpyridine-3-carboxamide |
| Canonical SMILES | CN(C)C(=O)C1=CN=CC(=C1)C2=CN=C3C(=C2)C(=CN3)C4=CC=CC=C4OC |
| 分子式 | C22H20N4O2 |
| 分子量 | 372.42 |
| 溶解度 | <37.24mg/ml in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene. |
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