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ENMD-1068 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ENMD-1068 hydrochloride图片
CAS NO:789488-77-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

ENMD-1068hydrochloride是一种具有抗血管生成和抗炎活性的选择性蛋白酶激活受体2(PAR2)拮抗剂。ENMD-1068hydrochloride可通过抑制TGF-β1/Smad信号转导而减少星状细胞活化和胶原蛋白表达。

Cas No.789488-77-3
别名6-氨基-1-[4-(3-甲基丁酰)哌嗪-1-基]己烷-1-酮,6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride
Canonical SMILESO=C(N1CCN(C(CC(C)C)=O)CC1)CCCCCN.Cl
分子式C15H30ClN3O2
分子量319.87
溶解度Water: 25 mg/mL, clear
储存条件Desiccated at 2-8℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist with antiangiogenic and anti-inflammatory activities. ENMD-1068 hydrochloride reduces epatic stellate cells (HSCs) activation and collagen expression through the inhibiton of TGF-β1/Smad signal transduction[1][2].

[1]. Yifeng Wang, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210(6):531.e1-8. [2]. Quan Sun, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7(1):5498.