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BTT 3033
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BTT 3033图片
CAS NO:1259028-99-3
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
BTT 3033 是一种口服活性的 α2β1 (EC50: 130 nM) 构象选择性抑制剂,通过与 α2I 结构域结合。
Cas No.1259028-99-3
Canonical SMILESFC1=CC=C(N2N=CC(S(N(C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)C)(=O)=O)=C2)C=C1
分子式C23H20FN5O3S
分子量465.5
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Selective inhibitor of integrin α2β1 (EC50 = 130 nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. Inhibits platelet aggregation to collagen I coated capillaries under flow. Also inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions.

Nissinen et al (2012) Novel a2 beta 1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J.Cell Biol. 287 44694 PMID:23132859