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LYG-202
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
LYG-202图片
CAS NO:1175077-25-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Cas No.1175077-25-4
Canonical SMILESCN1CCN(CCCCOC2=CC(O)=C(C(C=C(C3=CC=CC=C3)O4)=O)C4=C2OC)CC1
分子式C25H30N2O5
分子量438.5
溶解度DMF: 14 mg/ml,DMF:PBS (pH7.2) (1:40): 0.12 mg/ml,Ethanol: 2.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LYG-202 is a synthetic flavonoid with anticancer and anti-angiogenic activities. It inhibits proliferation of HepG2, MCF-7, HeLa, BGC-823, MDA-MB-435, and HCT116 cancer cells in vitro (IC50s = 4.74-27.70 μM) via induction of apoptosis and dissipation of the mitochondrial membrane potential. LYG-202 reduces tumor growth in S180 sarcoma cell-inoculated mice. It also inhibits VEGF-stimulated human umbilical vein endothelial cells (HUVEC) cell migration and tube formation in vitro and decreases capillary sprouting in isolated rat aortic rings and the chicken chorioallantoic membrane (CAM) model of angiogenesis.