Tirabrutinib hydrochloride(ONO-4059(hydrochloride))

您好，欢迎来到化工原料网！ [登录] [免费注册]

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1439901-97-9

包装与价格：

产品介绍

Tirabrutinib (ONO-4059) hydrochloride 是一种具有口服活性的 Bruton's Tyrosine Kinase (BTK) 抑制剂（可以穿过血脑屏障 (BBB)），IC50 为 6.8 nM。

Cas No.	1439901-97-9
别名	ONO-4059 hydrochloride; GS-4059 hydrochloride
Canonical SMILES	O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5.[H]Cl
分子式	C₂₅H₂₃ClN₆O₃
分子量	490.94
溶解度	DMSO: 17.86 mg/mL (36.38 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development. [1]. Akintunde Akinleye et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59. [2]. Harriet S et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood 2016, 127:411-419.