您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > Fradafiban(BIBU-52)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Fradafiban(BIBU-52)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Fradafiban(BIBU-52)图片
CAS NO:148396-36-5
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Fradafiban (BIBU-52) 是一种非肽血小板糖蛋白 IIb/IIIa 拮抗剂，可与人血小板 GP IIb/IIIa 复合物结合，Kd 值为 148 nM。
Cas No.148396-36-5
别名夫雷非班; BIBU-52
Canonical SMILESO=C(O)C[C@H]1C(N[C@H](COC2=CC=C(C3=CC=C(C(N)=N)C=C3)C=C2)C1)=O
分子式C20H21N3O4
分子量367.4
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.

Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM[1].

Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion[1].

[1]. Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8.