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Pexidartinib(PLX3397)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pexidartinib(PLX3397)图片
CAS NO:1029044-16-3
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品名称
PLX-3397, PLX 3397
产品介绍

生物活性

Pexidartinib (PLX3397)是KIT,CSF1R和FLT3的小分子酪氨酸激酶(RTK)抑制剂,具有潜在的抗肿瘤活性。

靶点信息

KitCSF-1RFlt3
10 nM20 nM160 nM

化学数据

目录号A15520
作用机制Inhibitor (抑制剂)
M. Wt417.81
FormulaC20H15ClF3N5
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1029044-16-3
SynonymsPLX-3397, PLX 3397
SMILESFC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F

溶解度

In vitro (25°C)DMSO71 mg/mL (169.93 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+45% PEG 300+5% Tween 80+ddH2O9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.93 mL119.67 mL239.34 mL
0.5 mM4.79 mL23.93 mL47.87 mL
1 mM2.39 mL11.97 mL23.93 mL
5 mM0.48 mL2.39 mL4.79 mL

*The above data is based on the productmolecular weight 417.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.