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RWJ 50271
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RWJ 50271图片
CAS NO:162112-37-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议

产品介绍
RWJ 50271 是一种选择性和口服活性的淋巴细胞功能相关抗原-1/细胞间粘附分子-1(LFA-1/ICAM-1)相互作用的抑制剂,IC50 为 5.0 μM(HL60 细胞)。
Cas No.162112-37-0
化学名(Z)-N-(3-hydroxypropyl)-5-methyl-1-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-1H-pyrazole-4-carbimidic acid
Canonical SMILESCC1=C(/C(O)=N/CCCO)C=NN1C2=NC(C3=CC(C(F)(F)F)=CC=C3)=CS2
分子式C18H17F3N4O2S
分子量410.41
溶解度<41.04mg/ml in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

RWJ 50271 is an selective inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells)[1].

References:
[1]. Sanfilippo PJ, et al. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J Med Chem. 1995 Mar 31;38(7):1057-9.