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Butyryltimolol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Butyryltimolol图片
CAS NO:106351-79-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Butyryltimolol 是Timolol 的有效前药。Timolol 可用于治疗青光眼,但难于透过角膜,Timolol 化学结构修饰后得到 Butyryltimolol,透过眼角膜的能力增强,进入眼球后,经酶水解再生成 Timolol 而起作用。Butyryltimolol 是一种 β-肾上腺素能 (β-adrenergic) 阻滞剂。
Cas No.106351-79-5
别名丁酰噻吗洛尔
分子式C17H30N4O4S
分子量386.51
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Butyryltimolol, an effective prodrug of Timolol, improves the corneal penetration of Timolol[1]. Butyryltimolol is a β-adrenergic blocker[2].

Butyryltimolol, a prodrug of Timolol, is equally effective as 240-min nasolacrimal blockade in enhancing ocular drug absorption[1].

[1]. Chang SC, et al. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69.
[2]. Potter DE, et al. Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol. Curr Eye Res. 1988 Aug;7(8):755-9.