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Usmarapride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Usmarapride图片
CAS NO:1428862-33-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Usmarapride (SUVN-D4010) 是一种有效的、具有选择性、口服活性和可透过血脑屏障的 5-HT4 受体部分激动剂 (EC50=nM)。Usmarapride (SUVN-D4010) 可用于阿尔茨海默病相关认知缺陷的研究。
Cas No.1428862-33-2
别名SUVN-D4010
分子式C23H31N5O6
分子量473.52
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) can be used for the research of cognitive deficits associated with Alzheimer’s disease[1].

Usmarapride (SUVN-D4010) (1-3 mg/kg; p.o.; Male Wistar rats 10-12 weeks old) attenuates the long-term memory deficits in object recognition test (ORT)[1].Usmarapride (1, 3, and 10 mg/kg; p.o.) significantly reverses the scopolamine-induced amnesia[1]. Usmarapride shows a statistically significant effect at 3.0 mg/kg on both exploration time and recognition index[1].Usmarapride (SUVN-D4010) shows good oral exposures, good bioavailability, and good brain exposures in rats[1].Pharmacokinetic of Usmarapride in Rats[1](3.0 mg/kg for p.o. dosing; 1.0 mg/kg for i.v.) F% Cmax (ng/mL) AUC (ng.hr/mL) t1/2 (h) Vdss (L/kg) CL (mLg/min/kg) 34 360 709 1.7 8.0 76

[1]. Nirogi, Ramakrishna; Mohammed, Abdul Rasheed; Yarlgadda, Suresh; Ravella, Srinivasa Rao; Shinde, Anil Karbhari; Kambhampati, Ramasastri; Roayalley, Praveen Kumar; Jayarajan, Pradeep; Bhyrapuneni, Gopinadh; Patnala, Sriramachandra Murthy; et al. Preparation of heteroaryl compounds as 5-HT4 receptor ligands.WO2013042135A1