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Ricinine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ricinine图片
CAS NO:524-40-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
蓖麻碱在 CCl4 诱导的肝损伤中表现出保肝作用。
Cas No.524-40-3
别名蓖麻鹼
Canonical SMILESN#CC1=C(C=CN(C)C1=O)OC
分子式C8H8N2O2
分子量164.2
溶解度DMSO: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ricinine is a piperidine alkaloid that has been found inR. communisand has diverse biological activities.1,2,3,4It is an inhibitor of acetylcholinesterase (AChE; IC50= 54.5 µg/ml).2It scavenges ABTS radicals and chelates iron (IC50s = 102.65 and 104.32 µg/ml, respectively). Ricinine is toxic to adultA. gambiaewhen used at a concentration of 0.04 mg/ml in a feeding assay.3It is also toxic to mice with an intraperitoneal LD50value of 340 mg/kg but an oral LD50value of 3,000 mg/kg.1It has been used as a biomarker of ricin poisoning.4

1.Franke, H., Scholl, R., and Aigner, A.Ricin and Ricinus communis in pharmacology and toxicology-from ancient use and "Papyrus Ebers" to modern perspectives and "poisonous plant of the year 2018"Naunyn Schmiedebergs Arch. Pharmacol.392(10)1181-1208(2019) 2.Khan, B.R., Ghous, T., Rasheed, A., et al.Evaluation of anti-acetylcholinesterase activity and antioxidant potential of ricinine (a central nervous system stimulant) isolated from Ricinius communis L.J. Chem. Soc. Pak.38(2)326-332(2016) 3.Wachira, S.W., Omar, S., Jacob, J.W., et al.Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiaeParasit. Vectors7312(2014) 4.Johnson, R.C., Lemire, S.W., Woolfitt, A.R., et al.Quantification of ricinine in rat and human urine: A biomarker for ricin exposureJ. Anal. Toxicol.29(3)149-155(2005)