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Sofpironium bromide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sofpironium bromide图片
CAS NO:1628106-94-4
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Sofpironium bromide (BBI 4000) 是一种抗胆碱能剂，用于研究原发性腋窝多汗症 (PAH)。Sofpironium bromide 通过抑制应用部位外分泌腺中的 M3 毒蕈碱受体来减少出汗。Sofpironium bromide 对 M1、M2、M4 和 M5 亚型也有很高的亲和力。
Cas No.1628106-94-4
别名BBI 4000
分子式C22H32BrNO5
分子量470.4
溶解度DMSO : 100 mg/mL (212.59 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes[1].

Sofpironium bromide is metabolized mainly through non-enzymatic hydrolysis, and also through oxidative metabolism via CYP2D6 and CYP3A4[1].

Sofpironium bromide exhibits anticholinergic activity by inhibiting the contractile activity of guinea pig ileal tissue in a concentration-dependent manner. In a rat model, Sofpironium bromide reduces footpad sweating induced by Pilocarpine (a muscarinic receptor agonist)[1].

[1]. Julia Paik, et al. Sofpironium Bromide: First Approval. Drugs. 2020 Dec;80(18):1981-1986.