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(±)-Penbutolol-d9 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)-Penbutolol-d9 hydrochloride图片
CAS NO:1346605-01-3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
(±)-Penbutolol-d9 hydrochloride ((Rac)-Penbutolol-d9) 是一种氘标记的 (±)-Penbutolol hydrochloride。(±)-Penbutolol hydrochloride 是一种 β-肾上腺素受体拮抗剂,IC50 为 0.74 μM。
Cas No.1346605-01-3
别名喷布特罗-D9,(Rac)-Penbutolol-d9 hydrochloride; (±)-Isopenbutolol-d9 hydrochloride
分子式C18H21D9ClNO2
分子量336.94
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(±)-Penbutolol-d9 ((Rac)-Penbutolol-d9) hydrochloride is a deuterium labeled (±)-Penbutolol hydrochloride. (+)-Penbutolol hydrochloride is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].

[1]. Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca(2+)-overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118(4):865-70.
[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.