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Ipidacrine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ipidacrine图片
CAS NO:62732-44-9
包装与价格:
包装价格(元)
500mg电议
1 g电议
5 g电议

产品介绍
2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-amine 是一种药物活性化合物,是一种促智剂,可作为胆碱酯酶抑制剂,用于治疗阿尔茨海默病 [1 ]。
Cas No.62732-44-9
别名伊匹达克林
Canonical SMILESNC1=C(CCC2)C2=NC3=C1CCCC3
分子式C12H16N2
分子量188.3
溶解度DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ipidacrine is an inhibitor of acetylcholinesterase (AChE; IC50= 270 nM).1It induces long-term potentiation (LTP) in rat hippocampal slices, an effect that can be blocked by the muscarinic antagonists atropine or pirenzepine , when used at a concentration of 10 µM.2Ipidacrine (0.03-1 mg/kg) prevents memory deficits induced by the anticholinergic agent scopolamine in the passive avoidance test in rats.2

1.Ogura, H., Kosasa, T., Kuriya, Y., et al.Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitroMethods Find. Exp. Clin. Pharmacol.22(8)609-613(2000) 2.Yoshida, S., and Suzuki, N.Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in ratsEur. J. Pharmacol.250(1)117-124(1993)