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15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α图片
CAS NO:1194396-71-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A nitric oxide-donating derivative of 17-phenyl trinor prostaglandin F2α
Cas No.1194396-71-8
Canonical SMILESO[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(NCC)=O)[C@H]1/C=C/[C@H](CCC2=CC=CC=C2)OC(CCCCCO[N+]([O-])=O)=O
分子式C31H46N2O8
分子量574.7
溶解度DMSO: 10 mg/ml,Ethanol: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension when administered topically at a concentration of 0.042%.

1.Impagnatiello, F., Toris, C.B., Batugo, M., et al.Intraocular pressure-lowering activity of NCX 470, a novel nitric oxide-donating bimatoprost in preclinical modelsInvest. Ophthalmol. Vis. Sci.56(11)6558-6564(2015)