RU-SKI 43 (hydrochloride) 是一种有效的选择性 Hedgehog 酰基转移酶 (Hhat) 抑制剂，IC50 为 850 nM。 RU-SKI 43 (hydrochloride) 通过 Smoothened-independent non-canonical 信号传导降低 Gli-1 活化并降低 Akt 和 mTOR 通路活性。 RU-SKI 43（盐酸盐）具有抗癌活性。
| Cas No. | 1782573-67-4 |
| 别名 | RU-SKI 43（盐酸盐） |
| Canonical SMILES | CC1=CC=CC(OCC2C(C=CS3)=C3CCN2C(CNCC(C)CC)=O)=C1.Cl |
| 分子式 | C22H30N2O2S•HCl |
| 分子量 | 423 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Hedgehog acyltransferase (Hhat) is an N-palmitoyltransferase that acylates Sonic hedgehog (Shh), which is critical for signaling through Shh. RU-SKI 43 is an inhibitor of Hhat (IC50 = 0.85 µM). It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a. RU-SKI 43 is cell-permeable and inhibits both autocrine and paracrine Shh-induced activation of Gli-mediated transcription. In pancreatic cancer cells, RU-SKI 43 reduces both Gli1 activation and proliferation. |
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