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Epiblastin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Epiblastin A图片
CAS NO:16470-02-3
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Epiblastin A 是一种 ATP 竞争性酪蛋白激酶 1 (CK1) 抑制剂，对 CK1α、CK1δ 和 CK1 ε 的 IC50 分别为 8.9、0.5 和 4.7 μM。 Epiblastin A 通过抑制 CK1 诱导外胚层干细胞重编程为胚胎干细胞。
Cas No.16470-02-3
化学名6-(3-chlorophenyl)-2,4,7-pteridinetriamine
Canonical SMILESNC1=NC2=NC(N)=NC(N)=C2N=C1C3=CC(Cl)=CC=C3
分子式C12H10ClN7
分子量287.7
溶解度Soluble in DMSO & DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms α, δ, and ε (IC50s = 8.9, 0.5, and 4.7 μM, respectively). [1] It is selective for CK1α, CK1δ, and CK1ε at concentrations below 10 μM, however, it also inhibits BRSK1, EEF2K, EGFR, MNK-2, and RIPK2 (IC50s = 24-45 μM). Epiblastan A reduces immunoprecipitation of CK1α, CK1δ, and CK1ε from HCT116 cell lysates in a concentration-dependent manner. It induces reprogramming of mouse epiblast stem cells (mEpiSCs) into embryonic stem cells (ESCs) 8-fold more efficiently than triamterene .

Reference:
[1]. Ursu, A., Illich, D.J., Takemoto, Y., et al. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of Casein Kinase 1. Cell Chem. Biol. 23(4), 494-507 (2016).