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24(S),25-epoxy Cholesterol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
24(S),25-epoxy Cholesterol图片
CAS NO:77058-74-3
包装:1mg
市场价:1134元

产品介绍
Cas No.77058-74-3
别名(24S)-24,25-环氧胆固醇,24(S)-24,25-EC
化学名(3β,24S)-24,25-epoxy-cholest-5-en-3-ol
Canonical SMILESCC1(C)[C@H](CC[C@@H](C)[C@@]2([H])CC[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@@]32C)O1
分子式C27H44O2
分子量400.6
溶解度Soluble in ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. [1] It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ.[2] It inhibits the conversion of demosterol to cholesterol by 3β-hydroxysterol δ24-reductase (DHCR24/Seladin-1) in CHO-7 and SRD-1 cells when used at a concentration of 2.5 μM. [3]

Reference:
[1]. Broccoli, V., and Caiazzo, M. Nuclear receptors: Oxysterols detour to neurodevelopment. Nat. Chem. Biol. 9(2), 70-71 (2013).
[2]. Nunomura, S., Endo, K., Makishima, M., et al. Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners. FEBS Lett. 584(6), 1143-1148 (2010).
[3]. Zerenturk, E.J., Kristiana, I., Gill, S., et al. The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). Biochim. Biophys. Acta. 1821(9), 1269-1277 (2012).