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JI051
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JI051图片
CAS NO:2234281-75-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
JI051是一种Hes1-PHB2相互作用稳定剂,能够与癌症相关蛋白伴侣prohibitin2(PHB2)相互作用,通过抑制Notch下游效应基因Hes1来诱导细胞周期停滞。具有抗肿瘤作用。
Cas No.2234281-75-3
Canonical SMILESO=C(NCCC1=CC=CC=C1OCC)/C=C/C2=CNC3=C2C=CC=C3OC
分子式C22H24N2O3
分子量364.44
溶解度DMSO : 125 mg/mL (342.99 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].

JI051 causes G2/M cell-cycle arrest[1].JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1]. Cell Proliferation Assay[1] Cell Line: HEK293 cells

[1]. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.