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Pyrintegrin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pyrintegrin图片
CAS NO:1228445-38-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Pyrintegrin 是一种 β1-整合素激动剂和 2,4-二取代嘧啶,可促进胚胎干细胞存活。
Cas No.1228445-38-2
化学名N-(cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]-benzenesulfonamide
Canonical SMILESOC1=CC2=C(C=C1)N(C3=CC=NC(NC4=CC=C(S(NCC5CC5)(=O)=O)C=C4)=N3)CCC2
分子式C23H25N5O3S
分子量451.5
溶解度≤1mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pyrintegrin, a 2,4-disubstituted pyrimidine, is a novel small-molecule inhibitor of BMP signaling which previously found to promote human embryonic stem cells survival [1].

Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily of secreted signaling molecules with important roles in many biological contexts. BMPs could bind to specificserine/threonine kinase receptors and transduce the signal to the nucleus through Smad proteins [2].

In vitro: Pyrintegrin induced differentiation of hADSCs into adipogenic‐like cells in vitro. Pyrintegrin drug treatment can accelerate adipocyte differentiation and augment lipid accumulation, adiponectin and fatty acid secretion in adipogenic medium differentiated human adipose derived stem cells [1]. Pyrimidine (2 μM) enhanced the survival of hESC more than 30-fold after trypsin-mediated dissociation. Pyrimidine increased integrin-dependent attachment of hESC to extracellular matrices without significantly impacting cell proliferation. Pyrintegrin increased the binding of the activated β1 integrin-specific antibody HUTS-21 and enhanced the phosphorylation of multiple growth factor receptors and their downstream kinases, PI3K and MAPK [3].

In vivo: Pyrintegrin promoted proliferation and differentiation of adipose precursor cells depending on their microenvironment. Pyrintegrin increased the number of preadipocytes and the rate of adipocyte differentiation, resulting in enhanced de novo adipogenesis [1].

References:
[1] Shah B S.  Pyrintegrin Induced Adipogenesis: Biology[D]. Columbia University, 2012.
[2] von Bubnoff A, Cho K W Y.  Intracellular BMP signaling regulation in vertebrates: pathway or network[J]. Developmental biology, 2001, 239(1): 1-14.
[3] Xu Y, Zhu X, Hahm H S, et al.  Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules[J]. Proceedings of the National Academy of Sciences, 2010, 107(18): 8129-8134.