CAS NO: | 175135-47-4 |
包装 | 价格(元) |
20mg | 电议 |
50mg | 电议 |
200mg | 电议 |
Cas No. | 175135-47-4 |
别名 | 2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈 |
化学名 | 2-(4-((4-methoxybenzyl)oxy)phenyl)acetonitrile |
Canonical SMILES | COC1=CC=C(COC2=CC=C(CC#N)C=C2)C=C1 |
分子式 | C16H15NO2 |
分子量 | 253.3 |
溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml,Ethanol: slightly |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | O4I1 is a potent Oct3/4 inducer implicated in promoting the expression and stabilization of Oct3/4. O4I1 can enhance the transcriptional activity of Oct3/4 in a variety of human somatic cells. Oct3/4, also known as POU5F1 and Oct4, is a transcription factor which is essential for self-renewal and pluripotency of embryonic stem cells. Oct3/4 is specifically expressed in the ES cells, epiblast, preimplantation embryos, and germ cells, et al [1]. When treated the synthesized cDNA from RNA isolated from the HEK293 cells with 10 μM and 20 μM O4I1 for 72 hrs, the Oct3/4 mRNA levels increased about 2.5- and 4-fold respectively. In human adult primary fibroblast (HF) and human neonatal foreskin fibroblast (HFF) cell lines, treatment with 10 μM O4I1 increased the gene and protein expression level of Oct3/4 after 72 hrs incubation in HF cells and 7 days in HFF cells. The derivatives of O4I1 such as compound 2, showed a time-dependent activation of Oct3/4 and markedly elevated the efficiency of Oct3/4 induction [1]. Reference: |