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O4I1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
O4I1图片
CAS NO:175135-47-4
包装与价格:
包装价格(元)
20mg电议
50mg电议
200mg电议

产品介绍
O4I1 是一种有效的 Oct3/4 诱导剂。
Cas No.175135-47-4
别名2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈
化学名2-(4-((4-methoxybenzyl)oxy)phenyl)acetonitrile
Canonical SMILESCOC1=CC=C(COC2=CC=C(CC#N)C=C2)C=C1
分子式C16H15NO2
分子量253.3
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml,Ethanol: slightly
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

O4I1 is a potent Oct3/4 inducer implicated in promoting the expression and stabilization of Oct3/4. O4I1 can enhance the transcriptional activity of Oct3/4 in a variety of human somatic cells. Oct3/4, also known as POU5F1 and Oct4, is a transcription factor which is essential for self-renewal and pluripotency of embryonic stem cells. Oct3/4 is specifically expressed in the ES cells, epiblast, preimplantation embryos, and germ cells, et al [1].

When treated the synthesized cDNA from RNA isolated from the HEK293 cells with 10 μM and 20 μM O4I1 for 72 hrs, the Oct3/4 mRNA levels increased about 2.5- and 4-fold respectively. In human adult primary fibroblast (HF) and human neonatal foreskin fibroblast (HFF) cell lines, treatment with 10 μM O4I1 increased the gene and protein expression level of Oct3/4 after 72 hrs incubation in HF cells and 7 days in HFF cells. The derivatives of O4I1 such as compound 2, showed a time-dependent activation of Oct3/4 and markedly elevated the efficiency of Oct3/4 induction [1].

Reference:
[1].Cheng X, Dimou E, Alborzinia H, et al. Identification of 2-[4-[(4-Methoxyphenyl) methoxy]-phenyl] acetonitrile and Derivatives as Potent Oct3/4 Inducers[J]. Journal of medicinal chemistry, 2015, 58(12): 4976-4983.