您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Windorphen
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Windorphen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Windorphen图片
CAS NO:19881-70-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
25mg电议

产品介绍
Cas No.19881-70-0
别名3-氯-2,3-双(4-甲氧苯基)丙烯醛
化学名(E)-3-chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
Canonical SMILESO=C/C(C1=CC=C(OC)C=C1)=C(Cl)\C2=CC=C(OC)C=C2
分子式C17H15ClO3
分子量302.75
溶解度≥ 11.45mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling for ventral development.

Wnt protein is a family of signaling proteins that interacts on the Wnt/β-Catenin pathways during embryotic development, cell proliferation, migration and adult tissue homeostasis.

In canonical Wnt/β-catenin reporter cell line STF293, Windorphen dose-dependently inhibits Wnt3a-inducible TOPFLASH-luciferase activity (IC50 of 1.5 mM). In human colon adenocarcinoma

SW480 cells with defective APC gene that constitutively activates Wnt signaling, 72 h treatment of Windorphen causes a wide spread apoptosis. [1]

In zebrafish embryos, Windorphen leads to apparent expansion of the dorsal markers (pax2.1) and marker of rhombomeres 3 and 5 at the six-somite stage (krox0). Windorphen selectively inhibits Wnt signaling in ventral and lateral regions of the 50% epiboly stage embryo (5.3 hpf). In addition, Windoprhen treatment rescues the telencephalon/eye phenotype in the mbl mutant zebrafish (i.e. a defective Axin1/β-catenin destruction complex causes abnormal activation of Wnt signaling and the loss of telencephalon and eyes.) [1]

Reference:
1.  Hao J, Ao A, Zhou L et al. Selective small molecule targeting β-catenin function discovered by in
vivo chemical genetic screen.  Cell Rep. 2013 Sep 12;4(5):898-904.