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ISX 9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ISX 9图片
CAS NO:832115-62-5
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
ISX 9 (Isoxazole 9) 是成人神经干细胞分化的有效诱导剂。
Cas No.832115-62-5
别名Isoxazole 9
化学名N-cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide
Canonical SMILESO=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3
分子式C11H10N2O2S
分子量234.27
溶解度≥ 23.4mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test.

References:
[1]. Petrik D, et al. Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule. FASEB J. 2012 Aug;26(8):3148-3162.