您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > 8Br-HA
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
8Br-HA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
8Br-HA图片
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
An FHIT inhibitor
Canonical SMILESO=C(OC1=C2C=CC(OCC(NO)=O)=C1Br)C3=C2CCCC3
分子式C15H14BrNO5
分子量368.2
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

8Br-HA is an inhibitor of fragile histidine triad diadenosine triphosphatase (FHIT; IC50= 0.12 µM).1It inhibits the growth of HCC827 and H460 lung cancer cells (GI50s = 0.87 and 5.9 µM, respectively).

1.Kawaguchi, M., Sekimoto, E., Ohta, Y., et al.Synthesis of fluorescent probes targeting tumor-suppressor protein FHIT and Identification of apoptosis-inducing FHIT inhibitorsJ. Med. Chem.64(13)9567-9576(2021)