CAS NO: | 106518-63-2 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
Cas No. | 106518-63-2 |
别名 | 灵芝马酮 |
Canonical SMILES | C[C@@]12C3=CC[C@](C)([C@]([C@@H](CC[C@H](O)[C@@](O)(C)CO)C)([H])CC4)[C@]4(C)C3=CC[C@@]1([H])C(C)(C(CC2)=O)C |
分子式 | C30H48O4 |
分子量 | 472.7 |
溶解度 | Chloroform: soluble |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Ganodermanontriol is a triterpene that has been found inG. lucidumand has diverse biological activities.1,2,3,4It inhibits the activity of HIV-1 protease (IC50= 70 µM), as well as reduces the activity of 5α-reductase by 32% when used at a concentration of 667 µM.1,2Ganodermanontriol (25 and 50 µM) inhibits proliferation, colony formation, invasion, and migration of MDA-MB-231 human breast cancer cells.3It reduces hepatocyte necrosis and increases in hepatic TNF-α and IL-6 levels in a mouse model of LPS/D-galactosamine-induced acute liver injury when administered at a dose of 5 mg/kg.4 1.Min, B.-S., Nakamura, N., Miyashiro, H., et al.Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 proteaseChem. Pharm. Bull.46(10)1607-1612(1998) 2.Liu, J., Kurashiki, K., Shimizu, K., et al.Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidumBioorg. Med. Chem.14(24)8654-8660(2006) 3.Jiang, J., Jedinak, A., and Silva, D.Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPABiochem. Biophys. Res. Commun.415(2)325-329(2011) 4.Hu, Z., Du, R., Xiu, L., et al.Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injuryCytokine127154917(2020) |